The Lena Smirnova Lab
Our Goal
Our research focuses on developing predictive, human-relevant in vitro models using iPSC-derived brain organoids and microphysiological systems to advance developmental neurotoxicology, gene × environment interactions, and disease modeling. We study the molecular mechanisms of cellular responses to environmental stress and their impact on brain development, connectivity, and function. By modeling learning and memory processes, synaptic plasticity, and neuroimmune interactions—such as through our microglia-integrated organoid (μbMPS) platform—we aim to create scalable systems that bridge fundamental neuroscience, environmental health, and translational research, moving toward more mechanistically informed and human-centered approaches to brain science.
